Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplas

New Exercise and Fitness Review

Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplas

Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia.

Int Neurourol J. 2014 Dec;18(4):179-86

Authors: Kim SK, Chung JH, Lee BC, Lee SW, Lee KH, Kim YO

Abstract
PURPOSE: Benign prostatic hyperplasia (BPH) is the most common prostate problem in older men. The present study aimed to investigate the inhibitory effect of Panax ginseng C.A. Meyer (P. ginseng) on a rat model of testosterone-induced BPH.
METHODS: The rats were divided into 3 groups (each group, n=10): control, testosterone-induced BPH (20 mg/kg, subcutaneous injection), and P. ginseng (200 mg/kg, orally) groups. After 4 weeks, all animals were sacrificed to examine the blood biochemical profiles, prostate volume, weight, histopathological changes, alpha-1D adrenergic receptor (Adra1d) mRNA expression, and epidermal growth factor receptor (EGFR) and B-cell CLL/lymphoma 2 (BCL2) protein expression.
RESULTS: The group treated with P. ginseng showed significantly lesser prostate size and weight than the testosterone-induced BPH group. In addition, P. ginseng decreased the mRNA expression of Adra1d as well as the expression of EGFR and BCL2 in prostate tissue.
CONCLUSIONS: These results suggest that P. ginseng may inhibit the alpha-1-adrenergic receptor to suppress the development of BPH.

PMID: 25558416 [PubMed]

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Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplas

The influence of combined oral contraceptives containing drospirenone on hypothalamic

New Exercise and Fitness Review

The influence of combined oral contraceptives containing drospirenone on hypothalamic

The influence of combined oral contraceptives containing drospirenone on hypothalamic-pituitary-adrenocortical axis activity and glucocorticoid receptor expression and function in women with polycystic ovary syndrome.

Hormones (Athens). 2014 Nov 5;

Authors: Macut D, Božic Antic I, Nestorov J, Topalovic V, Bjekic Macut J, Panidis D, Kastratovic Kotlica B, Papadakis E, Matic G, Vojnovic Milutinovic D

Abstract
OBJECTIVE: Most women with PCOS have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevation in urinary excretion of its metabolites. Increased cortisol clearance in PCOS is followed by a compensatory overdrive of the hypothalamic-pituitary-adrenocortical (HPA) axis. We hypothesized that oral contraceptives containing ethinylestradiol and drospirenone (EE-DRSP) could modulate glucocorticoid receptor (GR) expression and function and thus affect HPA axis activity in PCOS patients.
DESIGN: We analyzed 12 women with PCOS (age 24.17±4.88 years; body mass index 22.05±3.97 kg/m2) treated for 12 months with EE-DRSP and 20 BMI matched controls. In all subjects testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), cortisol (basal and after dexamethasone), concentrations of GR protein, phospo-GR211 protein, number of GR per cell (Bmax) and its equilibrium dissociation constant (KD) were measured.
RESULTS: Before treatment, increased concentrations of testosterone and DHEAS (p

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The influence of combined oral contraceptives containing drospirenone on hypothalamic

Nutrition - Study: sodium"s influence on blood pressure statistically insignificant

New Exercise and Fitness Review

Nutrition – Study: sodium’s influence on blood pressure statistically insignificant

A new study published in American Journal of Hypertension finds evidence that increased Body Mass Index, age, and non-sodium dietary factors are much more closely related to increases in systolic…

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Nutrition - Study: sodium"s influence on blood pressure statistically insignificant