Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplas

New Exercise and Fitness Review

Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplas

Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia.

Int Neurourol J. 2014 Dec;18(4):179-86

Authors: Kim SK, Chung JH, Lee BC, Lee SW, Lee KH, Kim YO

Abstract
PURPOSE: Benign prostatic hyperplasia (BPH) is the most common prostate problem in older men. The present study aimed to investigate the inhibitory effect of Panax ginseng C.A. Meyer (P. ginseng) on a rat model of testosterone-induced BPH.
METHODS: The rats were divided into 3 groups (each group, n=10): control, testosterone-induced BPH (20 mg/kg, subcutaneous injection), and P. ginseng (200 mg/kg, orally) groups. After 4 weeks, all animals were sacrificed to examine the blood biochemical profiles, prostate volume, weight, histopathological changes, alpha-1D adrenergic receptor (Adra1d) mRNA expression, and epidermal growth factor receptor (EGFR) and B-cell CLL/lymphoma 2 (BCL2) protein expression.
RESULTS: The group treated with P. ginseng showed significantly lesser prostate size and weight than the testosterone-induced BPH group. In addition, P. ginseng decreased the mRNA expression of Adra1d as well as the expression of EGFR and BCL2 in prostate tissue.
CONCLUSIONS: These results suggest that P. ginseng may inhibit the alpha-1-adrenergic receptor to suppress the development of BPH.

PMID: 25558416 [PubMed]

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Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplas

Epidermal growth factor receptor mutations in East European non-small cell lung cance

New Exercise and Fitness Review

Epidermal growth factor receptor mutations in East European non-small cell lung cance

Epidermal growth factor receptor mutations in East European non-small cell lung cancer patients.

Cell Oncol (Dordr). 2014 Dec 23;

Authors: Bichev SN, Marinova DM, Slavova YG, Savov AS

Abstract
BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutations are recurrently observed in non-small cell lung carcinomas (NSCLCs), and it has been found that they may serve as specific therapeutic targets. The aim of the present study was to determine the prevalence of EGFR gene mutations in NSCLCs in an East European (Bulgarian) population in different histological subtypes, in cytological versus histological samples and in primary versus metastatic lesions.
METHODS: In this study 1427 NSCLC samples were included. DNA was extracted from either formalin-fixed paraffin embedded (FFPE) tissues or cytology specimens and analyzed for the presence of 29 recurrent EGFR gene mutations using SARMS PCR.
RESULTS: EGFR gene mutations were found to occur significantly more often in female than in male patients (19.4.% vs. 5.4.%; p < 0.001), in adenocarcinomas than in squamous cell carcinomas or other histological subtypes (12.5.% vs. 6.2.%, and 7.6.%, respectively; p = 0.009), and in never smokers than in ex-smokers and current smokers (22.9.% vs. 8.5.% and 4.9.%, respectively; p < 0.001). No significant differences were observed in the occurrence of EGFR gene mutations in primary tumors compared to metastases (7.9.% vs. 11.2.%; p = 0.092), or in FFPE samples compared to cytological samples (8.9.% vs. 8.1.%; p = 0.813).
CONCLUSIONS: Our data show that the overall frequency of EGFR gene mutations in lung adenocarcinomas in the East European cohort studied is within the range of that observed in North American and West European populations, but that its frequency in squamous cell carcinomas is higher than that in any population reported to date. All specimens appeared to be suitable for EGFR gene mutation analysis, irrespective nature or origin.

PMID: 25534657 [PubMed - as supplied by publisher]

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Southern SARMs discount code for 10% off WCBB10
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discount code for 30% OFF entire store WORLD30

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Epidermal growth factor receptor mutations in East European non-small cell lung cance