Saturday 28 February 2015
We 'Mirin Vol 102: 21 Inspirational Transformations
New Exercise and Fitness Review
About The Author
We "Mirin Vol 102: 21 Inspirational Transformations
IGF - Rifampicin reduces advanced glycation end products and activates DAF-16 to incr
New Exercise and Fitness Review
Aging Cell. 2015 Feb 26;
Authors: Golegaonkar S, Tabrez SS, Pandit A, Sethurathinam S, Jagadeeshaprasad MG, Bansode S, Sampathkumar SG, Kulkarni MJ, Mukhopadhyay A
Abstract
Advanced glycation end products (AGEs) are formed when glucose reacts nonenzymatically with proteins; these modifications are implicated in aging and pathogenesis of many age-related diseases including type II diabetes, atherosclerosis, and neurodegenerative disorders. Thus, pharmaceutical interventions that can reduce AGEs may delay age-onset diseases and extend lifespan. Using LC-MS(E) , we show that rifampicin (RIF) reduces glycation of important cellular proteins in vivo and consequently increases lifespan in Caenorhabditis elegans by up to 60%. RIF analog rifamycin SV (RSV) possesses similar properties, while rifaximin (RMN) lacks antiglycation activity and therefore fails to affect lifespan positively. The efficacy of RIF and RSV as potent antiglycating agents may be attributed to the presence of a p-dihydroxyl moiety that can potentially undergo spontaneous oxidation to yield highly reactive p-quinone structures, a feature absent in RMN. We also show that supplementing rifampicin late in adulthood is sufficient to increase lifespan. For its effect on longevity, rifampicin requires DAF-18 (nematode PTEN) as well as JNK-1 and activates DAF-16, the FOXO homolog. Interestingly, the drug treatment modulates transcription of a different subset of DAF-16 target genes, those not controlled by the conserved Insulin-IGF-1-like signaling pathway. RIF failed to increase the lifespan of daf-16 null mutant despite reducing glycation, showing thereby that DAF-16 may not directly affect AGE formation. Together, our data suggest that the dual ability to reduce glycation in vivo and activate prolongevity processes through DAF-16 makes RIF and RSV effective lifespan-extending interventions.
PMID: 25720500 [PubMed - as supplied by publisher]
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Insulin like growth factors
IGF-1
Igf-1r3
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IGF - Rifampicin reduces advanced glycation end products and activates DAF-16 to incr
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Driven For Success
New Exercise and Fitness Review
Vital Stats
Name: Cory Gregory
Age: 34
Height: 5-foot-11
Weight: 185-190 lbs, 175 contest
Education: Exercise Specialist Degree: Columbus State University; NESTA Fitness Coach; CrossFit Level 1-Westside Barbell certified
Occupation: Co-Founder MusclePharm
Contest History: Competed in 14 bodybuilding shows over 20 powerlifting meets
I was up early to train as usual one morning in the summer of 2013, but something didn’t feel quite right. I knew that my goal—my assignment—was to kill it in the gym that day, but beyond that, I hadn’t really set any defined goals since doing a photo shoot for “FitnessRx Magazine” at the Arnold Classic earlier that year. Until that morning, I had been too busy to even notice that I’d fallen into a rut.
Ironically, that same morning one of the editors from Bodybuilding.com sent me a proof of my Fitness 360 feature. So, before training, I sat down and watched it for some inspiration. This video delved into my fitness journey, family and background, as well as my overall mindset in general. I loved it! And even though it was 4:10 a.m., a light bulb instantly clicked on in my head.
I realized that I spoke so confidently because my discipline was at an all-time high when we filmed. Why? Well, it had been shot at the Arnold Classic, when I was representing the company I co-founded, MusclePharm, and I was three days out from the biggest photo shoot of my life.
Immediately, I wanted that Cory back. I wanted my confidence at that level every day—starting that morning. I decided that from then on, I was going to treat every day like it was the day before a competition or photoshoot. I was going to be fit for anything! This approach paid off just a few months later, when I experienced the craziest three weeks of my fitness life.
The Picture-Perfect Day
I wasn’t “letting myself go” or anything when I made this decision, but I’ll be honest: I wasn’t 1-2 weeks away from cover shape, either. And I knew that getting there would start with the way I started my day.
A few years ago, I started the hashtag #upearlytotrain. As I explained in the article ,” it wasn’t because I wanted to brag to anyone, although it’s probably been used that way by someone else. No, I made it to keep myself accountable. To get up as early as I do every day, you need use every tool at your disposal! Here’s how my day started once I made the commitment:
Daily routine:
- 3:50-4:10 a.m.: Wake up, take Shred Matrix, drive to Old School Gym
- 5 a.m.: Walk in the door, down Assault, train until 6 a.m., drive to track
- 6:30-7:00 a.m.: Drive to the track for lunges, 1/4 mile to 1 mile
- 7:00-7:30 a.m.: Go to coffee shop, read Andrew Carnegie for inspiration
- 7:45 a.m.: Arrive at office, eat first meal
- 1 p.m.: Lunch, then 250 weighted crunches with a 25-pound plate behind my head, plus 50-100 ab wheels
- 6-9 p.m.: Get home, dinner with family, watch shows with wifey
- 10:30-11 p.m.: Bed, after doing some abs on the floor
You saw that right; I hit the track for lunges pretty much every day. They bring my legs up like nothing else, and if I wanted to look like I knew I could—like I knew I should—lunges had to be a big part of the equation. Some days I did them with a 30- or 40-pound weighted vest on, and some days I did them unweighted. I even brought along some friends a few times. But every day, I was cooked by the time I was done with them.
Being ripped for my 35th birthday was a goal I had always had, and I wasn’t going to backslide through it. I knew I needed the perfect training split and nutrition plan to make this work.
Of course, a program that intense probably wouldn’t have lasted long if I didn’t also know exactly why I was doing it. So I made some new goals. I knew I wanted to shoot a cover for Inside Fitness in Canada, and to have my second “Fitness Rx” cover as well. I also had plenty of new business goals. We had just recently signed Arnold Schwarzenegger, and I wanted to launch the Arnold Line with all the fanfare it deserved.
Somewhere in the middle of all this, I was also going to turn 35. Being ripped for my 35th birthday was a goal I had always had, and I wasn’t going to backslide through it. I knew I needed the perfect training split and nutrition plan to make this work.
Fit for Anything
Water
1-1/2 to 2 gallons
Organic burger
1 lb
Almonds
MusclePharm Amino1
1 serving
Fit For Anything
Bodyweight Walking Lunge
1 mile with 40-lb. vest
German Volume Arms:
Straight bar biceps curl
10 sets of 10 reps, 10 seconds restStraight bar push-down
10 sets of 10 reps, 10 seconds restAlternate dumbbell curl
10 sets of 10 reps, 10 seconds restSkullcrusher
10 sets of 10 reps, 10 seconds restWrist curl
10 sets of 10 reps, 10 seconds restSuperset
Band push-down
3-5 sets of 20 repsReverse curl
3-5 sets of 12 repsSuperset
Hyperextensions (Back Extensions)
3 sets of 30 repsToes to bar
3 sets of 10 reps
For all movements, perform 50 reps before moving to the next. Use weights that are as light as necessary. Perform entire series twice.
Dumbbell military press
50 repsLateral raise
50 repsFront raise
50 reps (raise to eye level)Arnold press
50 repsCable lateral raise
50 repsBent-over lateral raise
50 reps
HIIT cardio
10 seconds on, 10 seconds rest, for 10 minutes
Sunday: Rest
Cover to cover
In not too long, I had the opportunity to put all this discipline to the ultimate test. First, I hit the shoot for “Inside Fitness Canada,” on September 16. On September 17, my birthday, I celebrated by eating one sliver of pumpkin pie—my favorite. But it was hard to relax, because my next shoot, for “FitnessRx,” was going to be just two days later, in California.
On September 18, we launched the Arnold Line with a huge party in Venice Beach, and the next day, I was ready for my shoot. I went straight from there to Las Vegas for the Olympia trade show, where aside from all the wonderful craziness of the expo and the Bodybuildng.com supplement awards, I ended up shooting three more covers: “Physique 3D,” “Muscle & Body,” and “Physical.”
MusclePharm Arnold Series
Watch The Video – 0:19
I was as cool as could be through all of this, because I had complete confidence that my diet and training were up to par. But then I got home, and things got even crazier. My buddy, Nick Showman, called me and said, “Hey Cory, you know the Natural Ohio Bodybuilding Association show is on Oct 12. What are you looking like?”
I hung up and began to think about it. It had been five years since I’d been on a bodybuilding stage. That’s a long time, I told myself—but maybe that was exactly why I should do it. I had just witnessed all of the excitement around bodybuilding from hanging with Arnold and being at the Olympia Weekend, and now there was a show just two miles from my house, and my family could even attend. I was all in!
It had been five years since I’d been on a bodybuilding stage. That’s a long time, I told myself—but maybe that was exactly why I should do it.
I weighed about 173 pounds, and I wondered what I would look like at 165 pounds. Sure, I wouldn’t outsize anyone, but would anyone else be as lean as me? So I set my goal: Get crazy-peeled like I had never been before. And I was in a great position to get there.
Get yourself into similar shape and get ready to reap similar rewards!
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About The Author
Driven For Success