Epidermal growth factor receptor mutations in East European non-small cell lung cance

New Exercise and Fitness Review

Epidermal growth factor receptor mutations in East European non-small cell lung cance

Epidermal growth factor receptor mutations in East European non-small cell lung cancer patients.

Cell Oncol (Dordr). 2014 Dec 23;

Authors: Bichev SN, Marinova DM, Slavova YG, Savov AS

Abstract
BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutations are recurrently observed in non-small cell lung carcinomas (NSCLCs), and it has been found that they may serve as specific therapeutic targets. The aim of the present study was to determine the prevalence of EGFR gene mutations in NSCLCs in an East European (Bulgarian) population in different histological subtypes, in cytological versus histological samples and in primary versus metastatic lesions.
METHODS: In this study 1427 NSCLC samples were included. DNA was extracted from either formalin-fixed paraffin embedded (FFPE) tissues or cytology specimens and analyzed for the presence of 29 recurrent EGFR gene mutations using SARMS PCR.
RESULTS: EGFR gene mutations were found to occur significantly more often in female than in male patients (19.4.% vs. 5.4.%; p < 0.001), in adenocarcinomas than in squamous cell carcinomas or other histological subtypes (12.5.% vs. 6.2.%, and 7.6.%, respectively; p = 0.009), and in never smokers than in ex-smokers and current smokers (22.9.% vs. 8.5.% and 4.9.%, respectively; p < 0.001). No significant differences were observed in the occurrence of EGFR gene mutations in primary tumors compared to metastases (7.9.% vs. 11.2.%; p = 0.092), or in FFPE samples compared to cytological samples (8.9.% vs. 8.1.%; p = 0.813).
CONCLUSIONS: Our data show that the overall frequency of EGFR gene mutations in lung adenocarcinomas in the East European cohort studied is within the range of that observed in North American and West European populations, but that its frequency in squamous cell carcinomas is higher than that in any population reported to date. All specimens appeared to be suitable for EGFR gene mutation analysis, irrespective nature or origin.

PMID: 25534657 [PubMed - as supplied by publisher]

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Epidermal growth factor receptor mutations in East European non-small cell lung cance

A rare granulosa cell tumor presentation with virilization and cystic adnexal mass on

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A rare granulosa cell tumor presentation with virilization and cystic adnexal mass on

Related Articles A rare granulosa cell tumor presentation with virilization and cystic adnexal mass on three-dimensional ultrasound: a case report.

J Reprod Med. 2014 Jul-Aug;59(7-8):421-4

Authors: Tanouye S, Gada R, Famuyide A, Coddington C

Abstract
BACKGROUND: Androgen-producing granulosa cell tumors (GCTs) are rare but should be suspected in patients presenting with rapid onset virilization and a large cystic adnexal mass. Preoperative diagnosis is difficult. By ultrasound, completely cystic, estrogen-producing GCTs are uncommon, while 39% of reported androgenic GCTs are completely cystic. We report a case of a GCT presenting with virilization and initially characterized on 3-dimensional (3-D) ultrasound.
CASE: A 32-year-old woman, gravida 1 para 0010, presented with amenorrhea, rapid onset hirsutism, acne, a 15-lb (6,803 g) weight gain, and an 8.7-cm cystic adnexal mass. The mass was evaluated with 2-D ultrasound and characteristics were confirmed on 3-D ultrasound. No abnormal Doppler flow was noted. Initial laboratory values confirmed hyperandrogenemia. A laparoscopic right salpingo-oophorectomy was performed after thorough counseling, and pathology demonstrated an adult granulosa cell tumor. Postoperatively her androgen levels normalized and symptoms resolved within 6 weeks. She continues to pursue pregnancy.
CONCLUSION: Presentations of androgen-producing ovarian masses are rare; however, the possibility of an androgenic GCT should be considered in the presentation of a large, virilizing, cystic adnexal mass to facilitate appropriate counseling and management.

PMID: 25098035 [PubMed - indexed for MEDLINE]

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A rare granulosa cell tumor presentation with virilization and cystic adnexal mass on