New Exercise and Fitness Review
Hormones (Athens). 2014 Nov 5;
Authors: Macut D, Božic Antic I, Nestorov J, Topalovic V, Bjekic Macut J, Panidis D, Kastratovic Kotlica B, Papadakis E, Matic G, Vojnovic Milutinovic D
Abstract
OBJECTIVE: Most women with PCOS have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevation in urinary excretion of its metabolites. Increased cortisol clearance in PCOS is followed by a compensatory overdrive of the hypothalamic-pituitary-adrenocortical (HPA) axis. We hypothesized that oral contraceptives containing ethinylestradiol and drospirenone (EE-DRSP) could modulate glucocorticoid receptor (GR) expression and function and thus affect HPA axis activity in PCOS patients.
DESIGN: We analyzed 12 women with PCOS (age 24.17±4.88 years; body mass index 22.05±3.97 kg/m2) treated for 12 months with EE-DRSP and 20 BMI matched controls. In all subjects testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone binding globulin (SHBG), cortisol (basal and after dexamethasone), concentrations of GR protein, phospo-GR211 protein, number of GR per cell (Bmax) and its equilibrium dissociation constant (KD) were measured.
RESULTS: Before treatment, increased concentrations of testosterone and DHEAS (p
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The influence of combined oral contraceptives containing drospirenone on hypothalamic
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