Low testosterone levels are associated with poor peripheral bone mineral density and

New Exercise and Fitness Review

Low testosterone levels are associated with poor peripheral bone mineral density and

Low testosterone levels are associated with poor peripheral bone mineral density and quantitative bone ultrasound at phalanges and calcaneus in healthy elderly men.

Biol Res Nurs. 2015 Mar;17(2):169-74

Authors: Moran JM, Martin RR, Pedrera-Canal M, Alonso-Terron J, Rodriguez-Velasco FJ, Pedrera-Zamorano JD

Abstract
Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men. We examined 162 men aged 65-88 years and assessed total serum T concentrations. Total serum T < 300 ng/dL was used as the threshold for biochemical T deficiency. The sample was divided into low (n = 66) or normal (n = 96) T levels; both groups were matched for age, weight, height, and body mass index (p > .05 for all the comparisons). All measured bone parameters were higher in the normal serum T group (p < .05). Multiple regression analysis revealed that serum T was an independent predictor of both QUS at the calcaneus and phalangeal pBMD. Our data indicate that T is an independent determinant of QUS at the os calcis and pBMD at the phalanges in elderly Spanish men.

PMID: 25681270 [PubMed - in process]

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Low testosterone levels are associated with poor peripheral bone mineral density and

Relationships of sex steroid hormone levels in benign and cancerous breast tissue and

New Exercise and Fitness Review

Relationships of sex steroid hormone levels in benign and cancerous breast tissue and

Relationships of sex steroid hormone levels in benign and cancerous breast tissue and blood: A critical appraisal of current science.

Steroids. 2014 Dec 29;

Authors: Stanczyk FZ, Mathews BW, Sherman ME

Abstract
A systematic review of the literature on sex steroid measurement in breast tissue identified only 19 articles meeting the following criteria: menopausal status given; steroids measured in tissue homogenates by conventional RIA with a purification step or by mass spectrometry; and values reported per g tissue or per g protein. Twelve articles were analyzed in detail for: ratios of sex steroid hormone levels in cancerous or benign tissues to blood levels, stratified by menopausal status; ratios between the different hormone levels within tissues or within blood; and difference in these ratios between tissue and blood compartments. Estrogen and androgen concentrations varied greatly in benign and cancerous tissue and in blood between individuals. Postmenopausal, but not premenopausal, estradiol concentrations were significantly higher in cancerous compared to benign breast tissue. The estradiol/estrone ratio was lowest in premenopausal benign tissue, and substantially higher in premenopausal cancerous tissues and postmenopausal benign and cancerous tissues. Estradiol and estrone levels were considerably higher in tissue than in plasma in both premenopausal and postmenopausal women. Androgen levels were generally higher in the benign than the cancerous tissues, and tissue androgen levels were higher than in plasma, suggesting in situ aromatization of androgens to estrogens in breast cancer tissues. Limited available data on levels of hydroxylated estrogens in breast tissue compared to corresponding levels in plasma or urine were reviewed, but due to the paucity of studies no conclusions can presently be drawn regarding the relationship of the 2-hydroxyestrone:16?-hydroxyestrone ratio to breast cancer risk and genotoxic effects of 4-hydroxylated estrogens. Finally, data on hormone levels in breast adipose tissue were analyzed; high levels of androstenedione and testosterone and significant estrone and estradiol levels in breast adipocytes from postmenopausal breast cancer patients suggest an obesity-inflammation-aromatase axis occurring locally in breast tissue. The controversies regarding the source of intratumoral estrogens in the breast are summarized.

PMID: 25554581 [PubMed - as supplied by publisher]

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Relationships of sex steroid hormone levels in benign and cancerous breast tissue and

High circulating levels of CCL2 in patients with Klinefelter"s syndrome.

New Exercise and Fitness Review

High circulating levels of CCL2 in patients with Klinefelter’s syndrome.

Related Articles High circulating levels of CCL2 in patients with Klinefelter’s syndrome.

Clin Endocrinol (Oxf). 2014 Mar;80(3):465-7

Authors: Rotondi M, Coperchini F, Renzullo A, Accardo G, Esposito D, Groppelli G, Magri F, Cittadini A, Isidori AM, Chiovato L, Pasquali D

PMID: 23663065 [PubMed - indexed for MEDLINE]

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High circulating levels of CCL2 in patients with Klinefelter"s syndrome.

Nutrition - Mislabeling of fish "exposes consumers to harmful levels of mercury"

New Exercise and Fitness Review

A study of Chilean sea bass bought across 10 states finds that mercury levels vary drastically, even among fish purporting to be certified as having low mercury content.

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Nutrition - Mislabeling of fish "exposes consumers to harmful levels of mercury"