New Exercise and Fitness Review
Endocr Connect. 2015 Jan 19;
Authors: Dutta P, Mahendran B, Reddy KS, Ahluwalia J, Vaiphei K, Kochhar RK, Gupta P, Srinivasan A, Kumar M, Mukherjee KK, Shah VN, Parthan G, Bhansali A
Abstract
Introduction: The effectiveness and short-term safety of recombinant human growth hormone (r-hGH) in patients with acromegaly who develop growth hormone deficiency (GHD) after treatment, is not well established. Subjects and Methods: Ten subjects with acromegaly who had GHD were treated with r-hGH for six months. Control groups consisted of ten age, gender and body mass index matched healthy subjects and ten active acromegaly patients who were treatment naïve. Body composition, quality of life, muscle strength, lipid profile and cardiovascular risk factors were assessed in all subjects at baseline, and the same parameters were reassessed after 6 months of therapy with r-hGH in acromegaly with GHD. Repeat MRI of the sella was performed in treated subjects. Optical colonoscopy was done and biopsies were taken from multiple sites for proliferation indices (Ki-67). Result: The median duration of GHD was 17.8 months and dose of r-hGH administered was 5.7±1.5 µg/kg/d. There was improvement in bone mineral content (p 0.01), bone mineral density (p 0.04), muscle strength (p
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Human Growth Hormone - Efficacy of recombinant hGH therapy in cured acromegaly patien
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