Monday 30 June 2014
Ask The Muscle Prof: 'How Should I Use Eccentric Training For Growth?'
New Exercise and Fitness Review
Vital Stats
Name: Jacob Wilson
Education: PhD in Skeletal Muscle Physiology from Florida State
Occupation: Founder ABCbodybuilding.com
Website: jacobwilsonphd.com
Facebook: Jacob-Wilson
Q I’ve heard the eccentric phase of a lift is really important for growth. Should I slow the eccentric portion of the lift as much as possible to increase muscle mass and bust out of my plateau?
Ever since I was a teenager, I’ve been studying skeletal muscle growth. After decade or so, a PhD, and plenty of academic studies later, I can confidently say that scientists have still only scratched the surface as to what makes this elaborate process work. Conversely, they can’t say exactly what causes it to stop working, even though you are still training like you were when it was working.
Luckily, we learn more all the time. We know more than ever about the mechanisms which seem to be responsible for causing individuals to “plateau” when they were previously able to make gains so readily. Specifically, we’re pretty sure it has a lot to do with a type of cell in our body known as satellite cells.
These little growth bombs are ready and waiting in your body right now. I’m going to tell you how you can activate them through optimal eccentric loading, but also why it’s not a good idea to make the eccentric phase of your lifts longer than just a few seconds.
The Benefits of Eccentric Training
As many of you know, there are two active parts to a lift: the concentric (or lifting) phase, and the eccentric (or lowering) phase. Both phases trigger muscle growth, but sometimes they do it through different mechanisms; I discussed the four mechanisms in my Mass Class training article.
For example, when you lift the weight concentrically, you produce greater metabolic stress, which is why I advise people to emphasize the concentric when they are using certain styles of lifting such as blood flow restriction training.1
However, research has also shown that when you lengthen the muscle eccentrically, you can increase protein synthesis more than a concentric contraction.2 Why is this the case? For one, scientists have discovered in recent years that eccentric contractions release a chemical called phosphatidic acid, which encourages protein synthesis.3
There are two active parts to a lift: the concentric (or lifting) phase, and the eccentric (or lowering) phase.
My lab group recently conducted a study where we found that simply bathing muscle cells in phosphatidic acid made them increase in protein synthesis.4 To answer your next question: Yes, we also found that taking supplemental phosphatidic acid increased muscle growth.
But that chemical action is only one of the ways that eccentric training works. Another, as I mentioned earlier, is through the activation of satellite cells. These unique cells are located on the outside of muscles, and they respond to damage in their vicinity by transforming into immature muscle fibers. More specifically, they move to the damaged area and fuse to muscle, becoming a part of it.5
The result is increased muscle fiber size and the addition of the satellite cell’s nucleus to the muscle. The latter step is critical, because the nuclei in the muscle are primarily responsible for stimulating skeletal muscle protein synthesis and growth. The more nuclei you have, the greater your growth potential.
Sounds important, right? Sure enough, research has shown that individuals who plateau in their training can’t adequately activate satellite cells.6,7 To tap into this critical cell population for growth you have to maximize eccentric loading. So let’s get into how you can do that.
Find the Perfect Cadence
Research shows that faster speed eccentric contractions result in a release of more growth factors, more satellite cells, and greater protein synthesis than slow speed eccentric contractions.
Once people learn the growth power of eccentrics, their next step is often to slow the eccentric phase down as much as possible—sometimes 5 seconds or more—in hopes that it will lead to more growth. While this is logical, it actually doesn’t pan out.
Research shows that faster speed eccentric contractions result in a release of more growth factors, more satellite cells, and greater protein synthesis than slow speed eccentric contractions.8,9 Seems shocking but it’s true. Let me explain.
As many of you know, muscle tension occurs when the contractile proteins myosin and actin bind to each other or form what’s known as a “cross-bridge.” The more cross-bridges you utilize, the less tension any one cross-bridge will have to bear—and the lower the muscle damage will be.
The major downfall to slowing down your contractions to emphasize the eccentric contraction is that your body has more time to form cross-bridges. The result is less damage, lower protein synthesis and ultimately growth.
Thus, my advice is to control the eccentric contraction but not to slow it down much. If you are training arms, for example, take no more than 1-3 seconds to lower the weight.
How To Use Eccentric Overload
You may have heard that you’re stronger eccentrically than you can concentrically. It’s a great principle to know. So are you putting it into action?
When studies have tested lifters’ 1RM for concentric contractions and had them lift the same weight eccentrically, they found no differences in muscle growth between the contractions. Some studies indicated an advantage for the concentric contractions under these conditions!2,10
Thus, if you emphasize the eccentric contraction with the same weight you use for concentric contractions, you probably won’t see any added benefit over the concentric contraction. You have to go heavier!
Hamstring Curls
There are a number of ways to increase the eccentric load. The classic method is to use assisted negative reps, where you lift the weight yourself, and on the way down your partner presses down on the weight. A second way is to lift a weight with two limbs and lower it with one.
For example, if you’re doing hamstring curls with two legs on the way up, you can lower with only one leg.
Eccentric Training That Lives Up To The Hype
If all this talk about muscle damage has been enough to make you start feeling preemptive DOMS, you’re on the right track. This is advanced training material, and it’s not right for everybody. And even if it’s right for you, it’s not right all the time. So let’s recap and get your expectations in line.
A major reason plateaus are reached is because individuals no longer are able to activate satellite cells. The inability to activate satellite cells appears to be activated through overloading the eccentric portion of the lift.
In order to overload on the eccentric portion of the lift, use a controlled but relatively short eccentric phase of a lift, like 1-3 seconds maximum. Anything longer may hinder muscle damage and subsequent growth.
Finally, assisted negative repetitions can optimize protein synthesis and muscle growth. However, it’s crucial that you periodize this method, because it will lead to substantial muscle damage. Utilize it no more than once per week for the body part that needs the most work.
References
- Yasuda T, et al. Effects of blood flow restricted low-intensity concentric or eccentric training on muscle size and strength. PLoS One. 2012;7(12):e52843.
- Eliasson J, et al. Maximal lengthening contractions increase p70 S6 kinase phosphorylation in human skeletal muscle in the absence of nutritional supply. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1197-205.
- O’Neil TK, et al. The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions. J Physiol. 2009 Jul 15;587(Pt 14):3691-701.
- Joy JM, et al. Phosphatidic acid enhances mTOR signaling and resistance exercise induced hypertrophy. Nutr Metab (Lond). 2014 Jun 16;11:29.
- Rosenblatt JD, et al. Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Muscle Nerve. 1994 Jun;17(6):608-13.
- Bamman MM, et al. Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans. J Appl Physiol (1985). 2007 Jun;102(6):2232-9.
- Petrella JK, et al. Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis. J Appl Physiol (1985). 2008 Jun;104(6):1736-42.
- Moore DR, et al. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1153-9.
- Shepstone TN, et al. Short-term high- vs. low-velocity isokinetic lengthening training results in greater hypertrophy of the elbow flexors in young men. J Appl Physiol (1985). 2005 May;98(5):1768-76.
- Mayhew TP, et al. Muscular adaptation to concentric and eccentric exercise at equal power levels. Med Sci Sports Exerc. 1995 Jun;27(6):868-73.
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About The Author
Ask The Muscle Prof: "How Should I Use Eccentric Training For Growth?"
Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriv
New Exercise and Fitness Review
Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriv
elayed onset muscle soreness (DOMS) due to eccentric muscle activity is associated with inflammatory responses and production of reactive oxygen species (ROS) that sustain both inflammation and oxidative stress. Curcumin, a powerful promoter of anti-oxidant response, is one of the best-investigated natural products, and is now commercially available as a lecithin delivery system (Meriva®, Indena SpA, Milan) with improved bio-availability. The aim of this study was to test whether curcumin could attenuate damage from oxidative stress and inflammation related to acute muscle injury induced by eccentric continuous exerciseMethods:This was a randomised, placebo-controlled, single-blind pilot trial. Twenty male healthy, moderately active volunteers were randomised to curcumin given as the Phytosome® delivery system 1.g twice daily (200.mg curcumin b.i.d.) or matching placebo. Supplementation was initiated 48.hours prior to a downhill running test and was continued for 24.hours after the test (4.days in total). Muscle damage was quantified by magnetic resonance imaging, laboratory tests and histological analyses on muscle samples obtained 48.hours after the test. Patient-reported pain intensity was also recorded.Results:Subjects in the curcumin group reported less pain in the lower limb as compared with subjects in the placebo group, although significant differences were observed only for the right and left anterior thighs. Significantly fewer subjects in the curcumin group had MRI evidence of muscle injury in the posterior or medial compartment of both thighs. Increases in markers of muscle damage and inflammation tended to be lower in the curcumin group, but significant differences were only observed for interleukin-8 at 2.h after exercise. No differences in markers of oxidative stress and muscle histology were observedConclusions:Curcumin has the potential for preventing DOMS, as suggested by its effects on pain intensity and muscle injury. Larger studies are needed to confirm these results and further clarify the mechanism of action of curcumin.This has been an automated posting
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Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriv
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Caputo Training For RPS Pen State
New Exercise and Fitness Review
This is Justin Caputo’s latest squat video. Here he does 555lbs plus 30lbs in chains(585). He also worked up to an opening 510 deadlift(no video) expecting to pull 575. Justin also intends to crack Micheal Soongs historical list of 165lb squats but with no wraps. Justin is still training Bulgarian-John broz style, squatting 2x a day 5 days a week and 3x a day on Sundays!this is an automated powerlifting post
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Caputo Training For RPS Pen State
Sunday 29 June 2014
Tom Kallas Breaks All Time Raw Wrapped Record Squat! 677 @ 165!!!
New Exercise and Fitness Review
Past weekend competed at WUAP Nationals in Peoria, IL. Was able to break previous all time world record of 672.2 squat with wraps in 165lb class. I squatted 677.7 (307.5kg) at 165lbs (75kg). Can’t thank my teamenough for support for this meet.
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Tom Kallas Breaks All Time Raw Wrapped Record Squat! 677 @ 165!!!
Human Growth Hormone - hGH isoform differential immunoassays applied to blood samples
New Exercise and Fitness Review
Human Growth Hormone – hGH isoform differential immunoassays applied to blood samples
Growth Horm IGF Res. 2014 Jun 11;
Authors: Hanley JA, Saarela O, Stephens DA, Thalabard JC
Abstract
OBJECTIVE: To detect hGH doping in sport, the World Anti-Doping Agency (WADA)-accredited laboratories use the ratio of the concentrations of recombinant hGH (‘rec’) versus other ‘natural’ pituitary-derived isoforms of hGH (‘pit’), measured with two different kits developed specifically to detect the administration of exogenous hGH. The current joint compliance decision limits (DLs) for ratios derived from these kits, designed so that they would both be exceeded in fewer than 1 in 10,000 samples from non-doping athletes, are based on data accrued in anti-doping labs up to March 2010, and later confirmed with data up to February-March 2011. In April 2013, WADA asked the authors to analyze the now much larger set of ratios collected in routine hGH testing of athletes, and to document in the peer-reviewed literature a statistical procedure for establishing DLs, so that it be re-applied as more data become available.
DESIGN: We examined the variation in the rec/pit ratios obtained for 21,943 screened blood (serum) samples submitted to the WADA accredited laboratories over the period 2009-2013. To fit the relevant sex- and kit-specific centiles of the logs of the ratios, we classified ‘rec/pit’ ratios based on low ‘rec’ and ‘pit’ values as ‘negative’ and fitted statistical distributions to the remaining log-ratios. The flexible data-driven quantile regression approach allowed us to deal with the fact that the location, scale and shape of the distribution of the modeled ‘rec/pit’ ratios varied with the concentrations of the ‘rec’ and ‘pit’ values. The between-kit correlation of the ratios was included in the fitting of the DLs, and bootstrap samples were used to quantify the estimation error in these limits. We examined the performance of these limits by applying them to the data obtained from investigator-initiated hGH administration studies, and in athletes in a simulated cycling stage race.
RESULTS: The mean and spread of the distribution of the modeled log-ratios depended in different ways on the magnitude of the rec and pit concentrations. Ultimately, however, the estimated limits were almost invariant to the concentrations, and similar to those obtained by fitting simpler (marginal) log-normal and Box-Cox transformed distributions. The estimated limits were similar to the (currently-used) limits fitted to the smaller datasets analyzed previously. In investigator-initiated instances, the limits distinguished recent use of rec-hGH from non-use.
CONCLUSIONS: The distributions of the rec/pit ratios varied as a function of the rec and pit concentrations, but the patterns in their medians and spreads largely canceled each other. Thus, ultimately, the kit- and sex-specific ratio DL obtained from the simpler model was very close to the ‘curve of DLs’ obtained from the more complex one. Both were close to previously established limits.
PMID: 24973245 [PubMed - as supplied by publisher]
More…
Human growth hormone
HGH
GH
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Human Growth Hormone - hGH isoform differential immunoassays applied to blood samples
Oral Test effect
New Exercise and Fitness Review
Androil is “40 mg of testosterone undecanoate, based in oil (oleic acid) and sealed inside a capsule. Subtracting the ester weight, this equates to a dosage of approximately 25mg of raw testosterone per cap.”
~Andriol (testosterone undecanoate)
Aveed and Virigen is another brand name of the above.
REXTORO is a new upcoming oral but it seems to be exactly the same as the above.
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Oral Test effect
RFG found new helmet for you
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