Low testosterone levels are associated with poor peripheral bone mineral density and

New Exercise and Fitness Review

Low testosterone levels are associated with poor peripheral bone mineral density and

Low testosterone levels are associated with poor peripheral bone mineral density and quantitative bone ultrasound at phalanges and calcaneus in healthy elderly men.

Biol Res Nurs. 2015 Mar;17(2):169-74

Authors: Moran JM, Martin RR, Pedrera-Canal M, Alonso-Terron J, Rodriguez-Velasco FJ, Pedrera-Zamorano JD

Abstract
Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels. We examined the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men. We examined 162 men aged 65-88 years and assessed total serum T concentrations. Total serum T < 300 ng/dL was used as the threshold for biochemical T deficiency. The sample was divided into low (n = 66) or normal (n = 96) T levels; both groups were matched for age, weight, height, and body mass index (p > .05 for all the comparisons). All measured bone parameters were higher in the normal serum T group (p < .05). Multiple regression analysis revealed that serum T was an independent predictor of both QUS at the calcaneus and phalangeal pBMD. Our data indicate that T is an independent determinant of QUS at the os calcis and pBMD at the phalanges in elderly Spanish men.

PMID: 25681270 [PubMed - in process]

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World Class Bodybuilding Forum

Low testosterone levels are associated with poor peripheral bone mineral density and

Active coping towards predatory stress is associated with lower corticosterone and pr

New Exercise and Fitness Review

Active coping towards predatory stress is associated with lower corticosterone and pr

Active coping towards predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system.

Horm Behav. 2014 Aug 12;

Authors: Bowen MT, Hari Dass SA, Booth J, Suraev A, Vyas A, McGregor IS

Abstract
An active coping style displayed under stress – which involves proactive investigatory responses towards environmental threats – has been associated with reduced vulnerability to psychiatric illness. However, the neurobiological determinants of coping styles are not well understood. When rats are exposed to a naturalistic stressor (cat fur) in a group, some individuals in the group show robust active investigation of the stimulus while others show a passive response involving retreat, immobility and close aggregation with conspecifics. Here we explored endocrine and epigenetic correlates of these contrasting coping styles. Male Wistar rats (n=48) were exposed to cat fur in groups of 4 and the passive and active responders were identified and assessed for endocrine and epigenetic differences. Three days after the final cat fur exposure, active responders had substantially lower plasma levels of corticosterone and progesterone than passive responders. Plasma and testicular testosterone levels did not differ between active and passive responders. Active responders had markedly less methylation of the AVP CGCG promoter region located at base 4970 in the posterodorsal region of the medial amygdala but did not differ in the methylation status of the CCGG sequence located at base 2243. This is in agreement with prior research suggesting that AVP and progesterone act in opposition within the medial amygdala to modulate stress-related behaviours. The present study reports striking endocrine and epigenetic differences between active and passive responders, providing insight into potential systems involved in the manifestation of differing coping styles.

PMID: 25127982 [PubMed - as supplied by publisher]

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World Class Bodybuilding Forum

Active coping towards predatory stress is associated with lower corticosterone and pr